Predictive value of Bcl-2 and Bax protein expression for chemotherapeutic effect in gastric cancer - A pilot study

被引：26

作者：

Nakata, B ^{[1
]}

Muguruma, K ^{[1
]}

Hirakawa, K ^{[1
]}

Chung, YS ^{[1
]}

Yamashita, Y ^{[1
]}

Inoue, T ^{[1
]}

Matsuoka, T ^{[1
]}

Onoda, N ^{[1
]}

Kato, Y ^{[1
]}

Sowa, M ^{[1
]}

机构：

[1] Osaka City Univ, Sch Med, Dept Surg 1, Abeno Ku, Osaka 545, Japan

来源：

ONCOLOGY | 1998年 / 55卷 / 06期

关键词：

Bcl-2; Bax; chemotherapy; gastric cancer;

D O I：

10.1159/000011910

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated tissue staining for Bcl-2 and Bax proteins, which regulate apoptosis, as indicators of chemotherapeutic effect in patients with gastric cancer. In 23 patients with gastric carcinoma biopsy specimens were obtained endoscopically prior to chemotherapy and stained immunohistochemically with anti-Bcl-2 and anti-Bax antibodies. Patients then were treated with continuous infusion of 5-FU and cisplatin. No correlation was seen between chemotherapeutic effect and Bcl-2 or Bax alone. However, among the Bax-positive cases, the patients with Bcl-2-positive tumors were significantly more chemoresistant (p = 0.036) and had worse prognoses (p = 0.008) than Bcl-2-negative cases. Therefore, immunohistochemical staining for Bcl-2 protein may predict chemotherapeutic efficacy or guide specific therapeutic choices in treating Bax-positive tumors.

引用

页码：543 / 547

页数：5

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