Molecular epidemiology of rabies virus isolated from different sources during a bat-transmitted human outbreak occurring in Augusto Correa municipality, Brazilian Amazon

被引：27

作者：

Barbosa, Taciana Fernandes Souza ^{[1
]}

de Almeida Medeiros, Daniele Barbosa ^{[1
]}

da Rosa, Elizabeth Salbe Travassos ^{[1
]}

Casseb, Livia Medeiros Neves ^{[1
]}

Medeiros, Rita ^{[2
]}

Pereira, Armando de Souza ^{[1
]}

Vallinoto, Antonio Carlos Rosario ^{[3
]}

Vallinoto, Marcelo ^{[4
]}

Begot, Alberto Lopes ^{[5
]}

da Silva Lima, Reynaldo Jose ^{[5
]}

da Costa Vasconcelos, Pedro Fernando ^{[1
]}

Nunes, Marcio Roberto Teixeira ^{[1
]}

机构：

[1] Inst Evandro Chagas, Dept Arboviral & Febres Hemorrag, BR-66093020 Belem, Para, Brazil

[2] Fed Univ Para, Hosp Univ Joao Barros Barreto, BR-66059 Belem, Para, Brazil

[3] Fed Univ Para, Ctr Ciencias Biol, Dept Patol, Virol Lab, Belem, Para, Brazil

[4] Fed Univ Para, Lab Genet & Biol Mol, BR-66075900 Belem, Para, Brazil

[5] Secretaria Saude Publ Estado Para, Belem, Para, Brazil

来源：

VIROLOGY | 2008年 / 370卷 / 02期

关键词：

rabies virus; hematophagous bat; rabies outbreak; molecular epidemiology; Augusto Correa municipality;

D O I：

10.1016/j.virol.2007.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We genetically characterize rabies virus (RABV) strains isolated from human cases, domestic and wild animals during a human outbreak of bat-transmitted rabies in Augusto Correa municipality, Para state, Brazilian Amazon in 2005. Partial nucleotide sequences of the N gene (491 bp) were obtained for all strains, and phylogenetic analysis grouped these into two major clades (Para and Central-Southeast) and identified them as bat-related viruses genotype 1, Desmodus rotundus antigenic variant 3 (AgV3). A molecular clock was used to estimate the time of emergence for each RABV isolate. The molecular data from this study suggest the association of vampire bats with human and domestic animal cases reported in the outbreak, the circulation of at least two predominant lineages in the Para state, and also a geographic association to lineages dispersion. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：228 / 236

页数：9

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