The return of clonal marking sheds new light on human hematopoietic stem cells

被引：24

作者：

Lemischka, IR

Jordan, CT

机构：

[1] Princeton Univ, Dept Mol Biol, Lewis Thomas Lab 210, Princeton, NJ 08544 USA

[2] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40536 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 01期

关键词：

D O I：

10.1038/83115

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human hematopoietic stem cells are of vital scientific and clinical importance. Using high resolution clonal analysis, Dick and colleagues shed important new light on the developmental behavior of these cells in the context of an in vivo model system.

引用

收藏

页码：11 / 12

页数：2

相关论文

共 17 条

[1] Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice [J].

Barquinero, J ;

Segovia, JC ;

Ramírez, M ;

Limón, A ;

Güenechea, G ;

Puig, T ;

Briones, J ;

García, J ;

Bueren, JA .

BLOOD, 2000, 95 (10) :3085-3093

[2] ISOLATION OF A CANDIDATE HUMAN HEMATOPOIETIC STEM-CELL POPULATION [J].

BAUM, CM ;

WEISSMAN, IL ;

TSUKAMOTO, AS ;

BUCKLE, AM ;

PEAULT, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2804-2808

[3] Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice [J].

Bhatia, M ;

Wang, JCY ;

Kapp, U ;

Bonnet, D ;

Dick, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5320-5325

[4] INTRODUCTION OF A SELECTABLE GENE INTO PRIMITIVE STEM-CELLS CAPABLE OF LONG-TERM RECONSTITUTION OF THE HEMATOPOIETIC SYSTEM OF W/WV MICE [J].

DICK, JE ;

MAGLI, MC ;

HUSZAR, D ;

PHILLIPS, RA ;

BERNSTEIN, A .

CELL, 1985, 42 (01) :71-79

[5] Transduction of human CD34+CD38- bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors [J].

Guenechea, G ;

Gan, OI ;

Inamitsu, T ;

Dorrell, C ;

Pereira, DS ;

Kelly, M ;

Naldini, L ;

Dick, JE .

MOLECULAR THERAPY, 2000, 1 (06) :566-573

[6] Distinct classes of human stem cells that differ in proliferative and self-renewal potential [J].

Guenechea, G ;

Gan, OI ;

Dorrell, C ;

Dick, JE .

NATURE IMMUNOLOGY, 2001, 2 (01) :75-82

[7] Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population [J].

Hao, QL ;

Thiemann, FT ;

Petersen, D ;

Smogorzewska, EM ;

Crooks, GM .

BLOOD, 1996, 88 (09) :3306-3313

[8] CLONAL AND SYSTEMIC ANALYSIS OF LONG-TERM HEMATOPOIESIS IN THE MOUSE [J].

JORDAN, CT ;

LEMISCHKA, IR .

GENES & DEVELOPMENT, 1990, 4 (02) :220-232

[9]

Kim HJ, 2000, BLOOD, V96, P1

[10]

LEMISCHKA IR, 1992, CURR TOP MICROBIOL, V177, P59