Phenomics: the next challenge

被引：851

作者：

Houle, David ^{[1
]}

Govindaraju, Diddahally R. ^{[2
]}

Omholt, Stig ^{[3
,4
]}

机构：

[1] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA

[2] Harvard Univ, Brigham & Womens Hosp, Dept Pathol, Sch Med, Boston, MA 02115 USA

[3] Norwegian Univ Life Sci, Ctr Integrat Genet CIGENE, Dept Anim & Aquacultural Sci, N-1432 As, Norway

[4] Univ Oslo, Ctr Ecol & Evolutionary Synth, NO-0316 Oslo, Norway

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CARDIOVASCULAR-DISEASE ENTERPRISES; GENOME-WIDE ASSOCIATION; COMMON GENETIC-VARIANTS; BREAST-CANCER RISK; MAJOR SHAREHOLDERS; NATURAL-SELECTION; SEXUAL SELECTION; COMPLEX DISEASE; HEART; PREDICTION;

D O I：

10.1038/nrg2897

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype-phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes - the full set of phenotypes of an individual - lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.

引用

页码：855 / 866

页数：12

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