A single nucleotide polymorphism in the DNA polymerase gamma gene of Saccharomyces cerevisiae laboratory strains is responsible for increased mitochondrial DNA mutability

被引：22

作者：

Baruffini, Enrico

Lodi, Tiziana

Dallabona, Cristina

Foury, Francoise

机构：

[1] Catholic Univ Louvain, Unite Biochim Physiol, B-1348 Louvain, Belgium

[2] Univ Parma, Dept Genet Biol Microorganisms Anthropol Evolut, I-43100 Parma, Italy

来源：

GENETICS | 2007年 / 177卷 / 02期

关键词：

D O I：

10.1534/genetics.107.079293

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the Saccharomyces cerevisiae strains used for genome sequencing and functional analysis, the mitochondrial DNA replicase Mip1p contains a single nucleotide polymorphism changing the strictly conserved threonine 661 to alanine. This substitution is responsible for the increased rate of mitochondrial DNA point mutations and deletions in these strains.

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页码：1227 / 1231

页数：5

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