Crossing the nuclear envelope: Hierarchical regulation of nucleocytoplasmic transport

被引：416

作者：

Terry, Laura J. ^{[1
]}

Shows, Eric B. ^{[1
]}

Wente, Susan R. ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

SCIENCE | 2007年 / 318卷 / 5855期

关键词：

D O I：

10.1126/science.1142204

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transport of macromolecules between the nucleus and cytoplasm is a critical cellular process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is subject to multiple levels of control. Regulation is achieved by modulating the expression or function of single cargoes, transport receptors, or the transport channel. Each of these mechanisms has increasingly broad impacts on transport patterns and capacity, and this hierarchy of control directly affects gene expression, signal transduction, development, and disease.

引用

页码：1412 / 1416

页数：6

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