Seven cases of fatal aconite poisoning: Forensic experience in China

被引:35
作者
Liu, Qian [1 ]
Zhuo, Luo [1 ]
Liu, Liang [1 ]
Zhu, Shaohua [1 ]
Sunnassee, Ananda [1 ]
Liang, Man [1 ]
Zhou, Lan [1 ]
Liu, Yan [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Fac Forens Med, Wuhan 430030, Peoples R China
关键词
Aconitine; Aconitum; Fatal poisoning; Chuanwu; Caowu; QUANTITATIVE-ANALYSIS; HERBAL MEDICINES; HONG-KONG; ALKALOIDS; INGESTION; MONKSHOOD;
D O I
10.1016/j.forsciint.2011.05.009
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
030101 [法学理论]; 030111 [法律史学]; 100218 [急诊医学];
摘要
This paper presents seven fatal cases of aconite poisoning encountered in the Tongji Center for Medicolegal Expertise in Hubei (TCMEH), China, from 1999 to 2008 retrospectively. In six of the cases, deaths occurred after drinking homemade medicated liquor containing aconite, and in one case death was due to ingestion of traditional Chinese medication containing aconite. Forensic autopsy and pathological examinations ruled out the presence of physical trauma or life-threatening diseases. Diagnosis of aconite poisoning was made after postmortem toxicological analysis. Animal experiment was performed in one case demonstrating that the medicated liquor could cause death rapidly. We present the autopsy and histopathological findings, toxicological analysis, and results of animal experiment done on samples from those seven cases. As an important herbal Chinese medicine, Aconitum species deserve special attention, especially because it contains poisonous alkaloids. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:E5 / E9
页数:5
相关论文
共 29 条
[1]
The effects of Aconitum alkaloids on the central nervous system [J].
Ameri, A .
PROGRESS IN NEUROBIOLOGY, 1998, 56 (02) :211-235
[2]
Aconite poisoning presenting as hypotension and bradycardia [J].
Chan, Thomas Y. K. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2009, 28 (12) :795-797
[3]
Aconite poisoning [J].
Chan, Thomas Y. K. .
CLINICAL TOXICOLOGY, 2009, 47 (04) :279-285
[4]
CHAN TYK, 1994, VET HUM TOXICOL, V36, P546
[5]
CHAN TYK, 1994, VET HUM TOXICOL, V36, P452
[6]
Incidence of herb-induced aconitine poisoning in Hong Kong - Impact of publicity measures to promote awareness among the herbalists and the public [J].
Chan, TYK .
DRUG SAFETY, 2002, 25 (11) :823-828
[7]
Colombo ML, 2009, NAT PROD COMMUN, V4, P1551
[8]
A case of fatal poisoning with the aconite plant: quantitative analysis in biological fluid [J].
Elliott, SP .
SCIENCE & JUSTICE, 2002, 42 (02) :111-115
[9]
Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties [J].
Friese, J ;
Gleitz, J ;
Gutser, UT ;
Heubach, JF ;
Matthiesen, T ;
Wilffert, B ;
Selve, N .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 337 (2-3) :165-174
[10]
FU HL, 2004, ZHONG YAO CAI, V27, P149