Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice

被引：42

作者：

Price, DB

Honeybourne, D

Little, P

Mayon-White, RT

Read, RC

Thomas, M

Wale, MC

Fitzgerald, P

Weston, AR

Winchester, CC

机构：

[1] Univ Aberdeen, Foresterhill Hlth Ctr, Dept Gen Practice & Primary Care, Aberdeen AB25 2AY, Scotland

[2] Birmingham Heartlands Hosp, Dept Resp Med, Birmingham B9 5SS, W Midlands, England

[3] Univ Southampton, Aldermoor Hlth Ctr, Fac Hlth Med & Biol Sci, Primary Med Care Grp, Southampton SO16 5ST, Hants, England

[4] Inst Hlth Sci, Oxford OX3 7LF, England

[5] Univ Sheffield, Sch Med, Div Mol & Genet Med, Sheffield S10 2RX, S Yorkshire, England

[6] Minchinhampton, Minchinhampton Surg, Stroud GL6 9JF, Glos, England

[7] Queens Med Ctr, PHLS Antimicrobial Susceptibil Surveillance Unit, Nottingham NG7 2UH, England

[8] M TAG Pty Ltd, Chatswood, NSW 2067, Australia

[9] Univ Newcastle, Ctr Clin Epidemiol & Biostat, Newcastle, NSW 2308, Australia

[10] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia

[11] Hlth Technol Analysts Pty Ltd, Balmain, NSW 2041, Australia

[12] Healthworld Commun Grp, Reading RG7 1AT, Berks, England

[13] Oxford Pharma Genesis Ltd, Oxford OX13 5QJ, England

来源：

RESPIRATORY MEDICINE | 2004年 / 98卷 / 01期

关键词：

antibiotic prescribing; lower respiratory tract infection; community-acquired pneumonia mortality; retrospective analysis; England and Wales;

D O I：

10.1016/j.rmed.2003.08.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based antibiotic prescribing for lower respiratory tract infections (LRTI). Methods: Retrospective analysis of aggregated data for pneumonia mortality, influenza incidence, and antibiotic prescribing for LRTI in England and Wales during 12-week winter periods between 1993/94 and 1999/2000. Results: Winter antibiotic prescribing for LRTI showed a 30.0% decline since 1995/96. Over the same period, there was a 50.6% increase in winter excess pneumonia mortality adjusted for influenza incidence. Negative binomial regression analysis showed that the incidence of influenza alone had a significant association with winter pneumonia mortality (P<0.001). The analysis also showed the reduction in antibiotic prescribing had a small but significant association with mortality (P<0.001), when simultaneously modelling for influenza incidence.

引用

页码：17 / 24

页数：8

共 35 条

[1]

Anderson R N, 2001, Natl Vital Stat Rep, V49, P1

[2] Untitled [J].

Anderson, RH .

CARDIOLOGY IN THE YOUNG, 2001, 11 (01) :1-2

[3]

[Anonymous], 1998, PATH LEAST RESISTANC

[4]

[Anonymous], HLTH STAT Q

[5]

[Anonymous], HLTH TRENDS

[6]

*BRIT THOR SOC, 2001, BURD LUNG DIS STAT R

[7]

Cate T R, 1998, Semin Respir Infect, V13, P17

[8]

DAMIANI M, 2002, MANAGING PRESSURE

[9]

*DEP HLTH, 2001, FLU IMM CAMP

[10] Persistence of sulphonamide resistance in Escherichia coli in the UK despite national prescribing restriction [J].

Enne, VI ;

Livermore, DM ;

Stephens, P ;

Hall, LMC .

LANCET, 2001, 357 (9265) :1325-1328

← 1 2 3 4 →