Robo4 counteracts VEGF signaling

被引：23

作者：

Acevedo, Lisette M. ^{[1
,2
]}

Weis, Sara M. ^{[1
,2
]}

Cheresh, David A. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Univ Calif San Diego Canc Ctr, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2008年 / 14卷 / 04期

关键词：

D O I：

10.1038/nm0408-372

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Robo4 expression in emerging blood vessels can neutralize signaling through the angiogenic factor vascular endothelial growth factor ( VEGF) and maintain vessel integrity. The findings could lead to new therapeutic targets for angiogenesis and vascular leakage ( pages 448-453).

引用

收藏

页码：372 / 373

页数：3

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