Episodic secretion of activin A in pregnant women

被引:24
作者
Gallinelli, A
Gallo, R
Genazzani, AD
Matteo, ML
Caruso, A
Woodruff, TK
Petraglia, F
机构
[1] UNIV PISA,DEPT OBSTET & GYNECOL,I-56100 PISA,ITALY
[2] UNIV MODENA,I-41100 MODENA,ITALY
[3] UNIV CATTOLICA SACRO CUORE,ROME,ITALY
[4] NORTHWESTERN UNIV,LAB REPROD ENDOCRINOL MED,CHICAGO,IL
关键词
D O I
10.1530/eje.0.1350340
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the present study was to determine the characteristics of activin A secretion in women with normal and abnormal pregnancy. With this purpose, a prospective study was done to evaluate the putative pulsatile pattern of serum activin A in serial specimens of blood collected during a certain amount of time (every 15 min for 3 h). A group of pregnant women (N=24) participated in a cross-sectional study. They were subdivided into three groups: healthy pregnant women (N=8), patients with preterm labor (N=8) and patients with gestational diabetes (N=8) before and after insulin therapy. Secretory pulses of serum activin A were determined in all patients with a specific frequency and amplitude by using two different computerized analyses, i.e. DETECT and CLUSTER, Mean+/-SEM values of serum activin A were significantly higher in patients with preterm labor and gestational diabetes than in controls (p <0.01), showing a significant decrease following insulin therapy in diabetic patients (p <0.01). Specific pulses of serum activin A levels were observed in all women, The mean pulse frequency did not change significantly between healthy controls and the different pathological groups, Patients with gestational diabetes after insulin therapy showed a pulse frequency that was significantly higher than in controls (p <0.05). When the mean peak amplitude of activin A pulses was evaluated, patients with preterm labor or gestational diabetes showed values that were significantly higher than in healthy pregnant women (p <0.01). A significant, inverse correlation between pulse frequency and amplitude was found both in healthy pregnant women (p <0.05) and in patients with gestational diabetes (p <0.001). The present study showed that circulating activin A levels in pregnant women change in a pulsatile pattern whose pulse amplitude is modified in the presence of gestational diseases, such as preterm labor or gestational diabetes.
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页码:340 / 344
页数:5
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