Autoradiographic analysis and regulation of angiotensin receptor subtypes AT4, AT1, and AT(1-7) in the kidney

被引:18
作者
Handa, RK [1 ]
Handa, SE [1 ]
Elgemark, MKS [1 ]
机构
[1] Washington State Univ, Coll Vet Med, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA
关键词
mammalian and avian kidneys; angiotensins II; IV; and; 1-7; furosemide; puromycin aminonucleoside; nitric oxide inhibition; bilateral ureteral obstruction; water diuresis;
D O I
10.1152/ajprenal.2001.281.5.F936
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Receptor autoradiography revealed that angiotensin AT(4) receptors were abundantly expressed in normal mammalian (mouse, rat, gerbil, guinea pig, rabbit) and avian (sparrow, chicken, turkey) kidneys and were more extensively distributed than previously reported (including proximal and distal segments of the nephron, interstitium, renal artery, vein, and ureter). Angiotensin AT(4) receptors were generally found to be more abundant than angiotensin AT(1) receptors in mammalian kidneys, whereas angiotensin AT((1-7)) receptors were not detected in either mammalian or avian kidneys. Rats subjected to various chronic treatments were found to preferentially decrease kidney AT(4) receptor density (furosemide, puromycin aminonucleoside, nitro-L-arginine methyl ester), decrease kidney AT(1) receptor density (bilateral ureteral obstruction), or increase kidney AT(1) receptor distribution in the inner medulla (water diuresis). These results indicate that the AT(4) receptor can be expressed in numerous cell types within the normal kidney of several species. Furthermore, several models of renal dysfunction and injury have been identified that selectively alter kidney AT(4) density and may potentially aid in elucidating the role of this novel angiotensin receptor system in renal function.
引用
收藏
页码:F936 / F947
页数:12
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