Nef - an adaptor adaptor?

被引：49

作者：

Oldridge, J

Marsh, M

机构：

[1] Univ London Univ Coll, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

[2] Univ London Univ Coll, Dept Biochem, London WC1E 6BT, England

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(98)01318-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.

引用

收藏

页码：302 / 305

页数：4

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