Autophagy: process and function

被引：3164

作者：

Mizushima, Noboru ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Dept Physiol & Cell Biol, Tokyo 1138519, Japan

[2] Japan sci & Technol Agcy, Solut Oriented Res Sci & Technol, Tokyo 1020075, Japan

来源：

GENES & DEVELOPMENT | 2007年 / 21卷 / 22期

关键词：

ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; ISOLATED RAT HEPATOCYTES; GENOME-WIDE ASSOCIATION; PROGRAMMED CELL-DEATH; DROSOPHILA FAT-BODY; SACCHAROMYCES-CEREVISIAE; AMINO-ACIDS; NEURODEGENERATIVE DISEASE; EMBRYONIC-DEVELOPMENT;

D O I：

10.1101/gad.1599207

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps - sequestration, transport to lysosomes, degradation, and utilization of degradation products - and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.

引用

页码：2861 / 2873

页数：13

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