Sexual dimorphism in growth as measured by microknemometry:: Different responses to GH deficiency and exogenous GH administration

被引:9
作者
de Lama, MAR
Pérez-Romero, A
Hermanussen, M
Ariznavarreta, C
Tresguerres, JAF [1 ]
机构
[1] Univ Complutense, Sch Med, Dept Physiol, E-28040 Madrid, Spain
[2] Aschauhof, Altenhof, Germany
关键词
growth; microknemometry; sexual dimorphism; growth hormone; gonadal steroids; monosodium glutamate; neonatal imprinting; gonadotropins;
D O I
10.1159/000054368
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To monitor growth, a novel noninvasive leg length measurement technique, called microknemometry, which allows daily observation of tibial growth rate, was used. The rat exhibits a striking sex-related difference in postpubertal growth. Exogenous GH administration results in a sexually dimorphic response, affecting growth in normal young female rats but not in males. Here we investigated how chronic GH deficiency affects male and female rat growth patterns. The degree of growth rate recovery was investigated after exogenous GH administration to chronically deficient males and females. The deficiency was induced by neonatal monosodium glutamate (MSG) treatment. Since the neonatal gonadal environment plays an important role in the dimorphic growth pattern, neonatal androgenization of female rats with testosterone or neonatal feminization of male rats by castration was performed and the growth pattern monitored. MSG treatment decreased pituitary GH content and plasma IGF I levels in both sexes, but caused a less marked reduction of female rat tibial growth and body weight gain than in males. Additionally, only MSG-treated males showed decreased pituitary LH content, so that the dimorphic action of MSG on the gonadal axis may contribute to the observed differences in growth rate. GH administration was able to increase leg length in all MSG-treated rats but was more effective in females, despite a similar restoration of plasma IGF I levels in both sexes. Although neonatal castration of male rats resulted in a reduction of tibial growth rate and body weight, and neonatal testosterone administration to female rats caused a slight increase in body weight, a complete modification of the gender-dependent growth pattern was not achieved, indicating that appropriate steroid environment is also needed in puberty and adulthood.
引用
收藏
页码:210 / 219
页数:10
相关论文
共 48 条
  • [1] CLONIDINE POTENTIATES THE GROWTH-HORMONE RESPONSE TO A GROWTH-HORMONE RELEASING HORMONE CHALLENGE IN HYPOTHALAMIC GROWTH-HORMONE RELEASING HORMONE-DEFICIENT RATS
    ARCE, V
    BARROS, MG
    VARA, E
    LIMA, L
    TRESGUERRES, JAF
    DEVESA, J
    [J]. NEUROENDOCRINOLOGY, 1995, 61 (05) : 552 - 558
  • [2] HYPOTHALAMIC-PITUITARY FUNCTION IN ADULT-RATS TREATED NEONATALLY WITH MONOSODIUM GLUTAMATE
    BADGER, TM
    MILLARD, WJ
    MARTIN, JB
    ROSENBLUM, PM
    LEVENSON, SE
    [J]. ENDOCRINOLOGY, 1982, 111 (06) : 2031 - 2038
  • [3] LATE ENDOCRINE EFFECTS OF ADMINISTERING MONOSODIUM GLUTAMATE TO NEONATAL RATS
    BAKKE, JL
    LAWRENCE, N
    BENNETT, J
    ROBINSON, S
    BOWERS, CY
    [J]. NEUROENDOCRINOLOGY, 1978, 26 (04) : 220 - 228
  • [4] BANG P, 1995, ENDOCRINOLOGY, V136, P816
  • [5] BLOCH B, 1984, NATURE, V307, P272, DOI 10.1038/307272a0
  • [6] SEX DIFFERENCE IN GROWTH-HORMONE FEEDBACK IN THE RAT
    CARLSSON, LMS
    CLARK, RG
    ROBINSON, ICAF
    [J]. JOURNAL OF ENDOCRINOLOGY, 1990, 126 (01) : 27 - 35
  • [7] ENDOGENOUS HUMAN GROWTH-HORMONE (GH) MODULATES THE EFFECT OF GONADOTROPIN-RELEASING HORMONE ON PITUITARY-FUNCTION AND THE GONADOTROPIN-RESPONSE TO THE NEGATIVE FEEDBACK EFFECT OF TESTOSTERONE IN ADULT MALE TRANSGENIC MICE BEARING HUMAN GH GENE
    CHANDRASHEKAR, V
    BARTKE, A
    WAGNER, TE
    [J]. ENDOCRINOLOGY, 1988, 123 (06) : 2717 - 2722
  • [8] CHEEK DB, 1974, HDB PHYSIOLOGY END 2, V4, P159
  • [9] Sex steroid effects on the development and functioning of the growth hormone axis
    Chowen, JA
    GarciaSegura, LM
    GonzalezParra, S
    Argente, J
    [J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 1996, 16 (03) : 297 - 310
  • [10] DIFFERENTIAL-EFFECTS OF THE NEONATAL AND ADULT SEX STEROID ENVIRONMENTS ON THE ORGANIZATION AND ACTIVATION OF HYPOTHALAMIC GROWTH HORMONE-RELEASING HORMONE AND SOMATOSTATIN NEURONS
    CHOWEN, JA
    ARGENTE, J
    GONZALEZPARRA, S
    GARCIASEGURA, LM
    [J]. ENDOCRINOLOGY, 1993, 133 (06) : 2792 - 2802