Anti-cytoldne therapies for psoriasis

被引：41

作者：

Nograles, Kristine E. ^{[1
]}

Krueger, James G. ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Invest Dermatol, New York, NY 10065 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2011年 / 317卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Psoriasis; Anti-cytokine therapy; TNF; IL-12/23p40; IL-23; IL-17; CHRONIC PLAQUE PSORIASIS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; RHEUMATOLOGY BIOLOGICS REGISTER; RANDOMIZED CONTROLLED-TRIAL; CYTOTOXIC T-LYMPHOCYTE; NECROSIS-FACTOR-ALPHA; CONTROLLED PHASE-III; DENDRITIC CELLS; DOUBLE-BLIND; ANTIMICROBIAL PEPTIDE;

D O I：

10.1016/j.yexcr.2011.01.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNE-alpha, or the p40 sub-unit of IL-12 and IL-23. However, the field is currently evolving to test more selective antagonists, such as anti-IL-23p19, IL-17 and other inflammatory cytokines. Here we discuss our current understanding of dendritic cell and T cell subsets that are relevant in psoriasis, and the pharmacologic strategies that temper their activity in this disease. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1293 / 1300

页数：8

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