Long-term recording system based on field-effect transistor arrays for monitoring electrogenic cells in culture

This paper describes the use of a PC-based system for acquisition and processing of data recorded from electrical active and excitable cells cultured over microfabricated arrays of field-effect transistors. Using these recording devices, limitations of conventional recording techniques such as those associated with making long-term and multisite recordings can be overcome. This system has been tested using neonatal rat cardiac myocytes, the beating of which is correlated with simultaneous recorded intra- and extracellular voltage measurements. (C) 1998 Elsevier Science S.A. All rights reserved.