Molecular mechanisms of filovirus cellular trafficking

被引：29

作者：

Aman, MJ

Bosio, CM

Panchal, RG

Burnett, JC

Schmaljohn, A

Bavari, S

机构：

[1] Clin Res Management Inc, Frederick, MD 21702 USA

[2] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, USAMRIID, Frederick, MD 21702 USA

[3] NCI, SAIC, Target Struct Based Drug Discovery Grp, Dev Therapeut Program, Frederick, MD 21702 USA

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 07期

关键词：

filovirus; assembly; budding; viral entry; rafts; endocytic pathway;

D O I：

10.1016/S1286-4579(03)00095-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with other phylogenetically or functionally related viruses, utilize a complex mechanism of replication exploiting multiple cellular components including lipid rafts, endocytic compartments, and vacuolar protein sorting machinery. In this review, we summarize these recent findings and discuss the implications for vaccine and therapeutics development. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

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收藏

页码：639 / 649

页数：11

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