Conformations of long deoxyribonucleic acid molecule on silicon surface observed by atomic force microscopy

被引：5

作者：

Ueda, M ^{[1
]}

Kawai, T ^{[1
]}

Iwasaki, H ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, ISIR, Ibaraki, Osaka 567, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS | 1998年 / 37卷 / 6A期

关键词：

DNA; silicon; AFM; step bunching; polyamine; supercoil;

D O I：

10.1143/JJAP.37.3506

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

By means of atomic force microscopy (AFM), the conformational structures of the circular double-stranded Deoxyribonucleic Acid (DNA) (2.96 kilobase pairs) on step-controlled silicon surface are studied. The DNA molecules observed an the terrace region maintain the supercoiled structure. On the other hand, the DNA molecules observed on the step-hunched region have a modified higher-order structure. Thus, we clarify that the conformations of long DNA are affected by the surface morphology of the substrate.

引用

页码：3506 / 3507

页数：2

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