Adsorbent screening for metal impurity removal in pharmaceutical process research

被引：217

作者：

Welch, CJ ^{[1
]}

Albaneze-Walker, J ^{[1
]}

Leonard, WR ^{[1
]}

Biba, M ^{[1
]}

DaSilva, J ^{[1
]}

Henderson, D ^{[1
]}

Laing, B ^{[1
]}

Mathre, DJ ^{[1
]}

Spencer, S ^{[1
]}

Bu, XD ^{[1
]}

Wang, TB ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 02期

关键词：

D O I：

10.1021/op049764f

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A microtube screening approach affords simple and convenient assessment of the selective adsorption of metal impurities by a variety of different process adsorbents. This approach is helpful in identifying rapid solutions to metal impurity problems in pharmaceutical process research. Several examples illustrating the utility of the approach are presented.

引用

收藏

页码：198 / 205

页数：8

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