Neutrophil chemiluminescence during phagocytosis is inhibited by abnormally elevated levels of acetoacetate: Implications for diabetic susceptibility to infections

被引：33

作者：

Saeed, FA ^{[1
]}

Castle, GE ^{[1
]}

机构：

[1] St Marys Coll, Dept Biol, Moraga, CA 94575 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1998年 / 5卷 / 05期

关键词：

D O I：

10.1128/CDLI.5.5.740-743.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human neutrophils by a chemiluminescence assay exhibit diminished phagocytic activity in the presence of abnormally high levels of the serum metabolite acetoacetate. These findings, along with our previous evidence demonstrating myeloperoxidase inhibition by acetoacetate, implicate metabolic ketosis in the inhibition of neutrophil microbicidal activity and thus in increased susceptibility to infections.

引用

页码：740 / 743

页数：4

共 13 条

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