Synthesis and pharmacology of a new AMPA-kainate receptor agonist with potent convulsant activity

被引:14
作者
Conti, P
De Amici, M
De Sarro, G
Stensbol, TB
Brauner-Osborne, H
Madsen, U
De Micheli, C
机构
[1] Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy
[2] Univ Catanzaro, Cattedra Farmacol, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy
[3] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark
关键词
D O I
10.1021/jm9803020
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:3759 / 3762
页数:4
相关论文
共 23 条
[1]  
Bigge CF, 1996, CURR PHARM DESIGN, V2, P397
[2]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[3]   INHIBITION OF [H-3] KAINIC ACID RECEPTOR-BINDING BY DIVALENT-CATIONS CORRELATES WITH ION AFFINITY FOR THE CALCIUM-CHANNEL [J].
BRAITMAN, DJ ;
COYLE, JT .
NEUROPHARMACOLOGY, 1987, 26 (09) :1247-1251
[4]   A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid [J].
Brauner-Osborne, H ;
Slok, FA ;
Skjaerbaek, N ;
Ebert, B ;
Sekiyama, N ;
Nakanishi, S ;
KrogsgaardLarsen, P .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (16) :3188-3194
[5]   Pharmacology and functions of metabotropic glutamate receptors [J].
Conn, PJ ;
Pin, JP .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :205-237
[6]   EXCITATORY AMINO-ACID NEUROTRANSMISSION THROUGH BOTH NMDA AND NON-NMDA RECEPTORS IS INVOLVED IN THE ANTICONVULSANT ACTIVITY OF FELBAMATE IN DBA/2 MICE [J].
DESARRO, G ;
ONGINI, E ;
BERTORELLI, R ;
AGUGLIA, U ;
DESARRO, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 262 (1-2) :11-19
[7]   SEIZURE SUSCEPTIBILITY IN DBA AND C57 MICE - THE EFFECTS OF VARIOUS CONVULSANTS [J].
ENGSTROM, FL ;
WOODBURY, DM .
EPILEPSIA, 1988, 29 (04) :389-395
[8]   QUANTITATIVE STUDIES ON SOME ANTAGONISTS OF N-METHYL D-ASPARTATE IN SLICES OF RAT CEREBRAL-CORTEX [J].
HARRISON, NL ;
SIMMONDS, MA .
BRITISH JOURNAL OF PHARMACOLOGY, 1985, 84 (02) :381-391
[9]   CLONED GLUTAMATE RECEPTORS [J].
HOLLMANN, M ;
HEINEMANN, S .
ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 :31-108
[10]   COMPLEX STRUCTURE OF QUISQUALATE-SENSITIVE GLUTAMATE RECEPTORS IN RAT CORTEX [J].
HONORE, T ;
NIELSEN, M .
NEUROSCIENCE LETTERS, 1985, 54 (01) :27-32