Cytokine, activation marker, and chemokine receptor expression by individual CD4+ memory T cells in rheumatoid arthritis synovium

被引：53

作者：

Nanki, T

Lipsky, PE

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

[2] Univ Texas, SW Med Ctr, Harold C Simmons Arthrit Res Ctr, Dallas, TX USA

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 05期

关键词：

chemokine receptor; cytokine; rheumatoid arthritis; T lymphocyte;

D O I：

10.1186/ar120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IL-10, IL-13, IFN-gamma, tumor necrosis factor (TNF)-alpha, LT-alpha, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4(+) memory T cells, whereas CD4(+) cells that produced IL-2, IL-4, or IL-6 were not detected. Expression of none of these molecules by individual CD4+ cells correlated with the exception of TRANCE and IL-10, and TRANCE and TNF-alpha. A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected.

引用

页码：415 / 423

页数：9

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