Genetic variants in peroxisome proliferator-activated receptor-γ gene are associated with risk of lung cancer in a Chinese population

被引：18

作者：

Chen, Dan ^{[2
,3
]}

Jin, Guangfu ^{[4
]}

Wang, Ying ^{[1
]}

Wang, Haifeng ^{[1
]}

Liu, Hongliang ^{[2
,3
]}

Liu, Yanhong ^{[2
,3
]}

Fan, Weiwei ^{[2
,3
]}

Ma, Hongxia ^{[4
]}

Miao, Ruifeng ^{[4
]}

Hu, Zhibin ^{[4
]}

Sun, Weiwei ^{[1
]}

Qian, Ji ^{[1
,2
,3
]}

Jin, Li ^{[2
,3
]}

Wei, Qingyi ^{[5
]}

Shen, Hongbing ^{[4
]}

Huang, Wei ^{[1
]}

Lu, Daru ^{[2
,3
]}

机构：

[1] Chinese Natl Human Genome Ctr, Dept Genet, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

[3] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[4] Nanjing Med Univ, Dept Epidemiol & Biostat, Ctr Canc Res, Nanjing 210029, Peoples R China

[5] Univ Texas Houston, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

来源：

CARCINOGENESIS | 2008年 / 29卷 / 02期

关键词：

D O I：

10.1093/carcin/bgm285

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulating evidence indicates that activation of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) dampens the inflammation cascade and inhibits tumor growth of the lung, suggesting that it has tumor suppressor functions. We performed a case-control study of 500 incident lung cancer cases and 517 age- and sex frequency-matched cancer-free controls in a Chinese population to investigate the role of 11 selected single nucleotide polymorphisms (SNPs) of PPAR-gamma in the etiology of lung cancer. We found that decreased lung cancer risk was statistically significantly associated with seven SNPs (P = 0.0004 for rs13073869 and 0.0130 for rs1899951 in a dominant model; P = 0.0310 for rs4135247 in a log-additive model; and P = 0.0468 for rs2972162, 0.0175 for rs709151, 0.0172 for rs11715541 and 0.0386 for rs1175543 in an overdominant model). Consistent with these results of single-locus analysis, both the haplotype and the diplotype analyses revealed a protective effect of the haplotype 'AGA' and 'AAA' of rs13073869, rs1899951 and rs4135247. Furthermore, we observed a statistically significant interaction between the rs1899951 and cigarette smoking. Our results indicate that PPAR-gamma polymorphisms and their interaction with smoking may contribute to the etiology of lung cancer. These findings need to be validated in larger, preferably population-based, studies including different ethnic groups.

引用

页码：342 / 350

页数：9

共 48 条

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