A cognitive neuropsychological model of antidepressant drug action

被引：95

作者：

Pringle, A. ^{[1
]}

Browning, M. ^{[1
]}

Cowen, P. J. ^{[1
]}

Harmer, C. J. ^{[1
]}

机构：

[1] Univ Oxford, Warneford Hosp, Dept Psychiat, Univ Dept Psychiat, Oxford OX3 7JX, England

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 07期

基金：

英国医学研究理事会;

关键词：

Antidepressants; Emotional processing; Functional neuroimaging; ADULT HIPPOCAMPAL NEUROGENESIS; SEROTONIN REUPTAKE INHIBITORS; HAPPY FACIAL EXPRESSIONS; SELECTIVE SEROTONIN; STARTLE MODULATION; CHRONIC FLUOXETINE; MAJOR DEPRESSION; FEAR RECOGNITION; NEURAL RESPONSE; STIMULI;

D O I：

10.1016/j.pnpbp.2010.07.022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. In this paper we consider the evidence to suggest that early changes in emotional processing underlie subsequent mood improvement following antidepressant treatment. Negative biases in information processing are consistently found in depression, and we argue that primary mode of action of antidepressant drugs may be to remediate these biases providing a more positive social environment in which the patient can relearn emotional associations fostering later improvement in mood. Evidence from behavioural and functional magnetic resonance imaging studies supports this hypothesis. Experimental medicine models developed under this premise have the potential to screen for new treatments, to predict individual treatment response and to consider the effects of pharmacological vs psychological treatments. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1586 / 1592

页数：7

共 71 条

[1] High-speed Imaging reveals neurophysiological links to behavior in an animal model of depression [J].

Airan, Raag D. ;

Meltzer, Leslie A. ;

Roy, Madhuri ;

Gong, Yuqing ;

Chen, Han ;

Deisseroth, Karl .

SCIENCE, 2007, 317 (5839) :819-823

[2] Affective startle modulation in clinical depression: Preliminary findings [J].

Allen, NB ;

Trinder, J ;

Brennan, C .

BIOLOGICAL PSYCHIATRY, 1999, 46 (04) :542-550

[3] Escitalopram effects on insula and amygdala BOLD activation during emotional processing [J].

Arce, Estibaliz ;

Simmons, Alan N. ;

Lovero, Kathryn L. ;

Stein, Murray B. ;

Paulus, Martin P. .

PSYCHOPHARMACOLOGY, 2008, 196 (04) :661-672

[4] Early effects of mirtazapine on emotional processing [J].

Arnone, D. ;

Horder, J. ;

Cowen, P. J. ;

Harmer, C. J. .

PSYCHOPHARMACOLOGY, 2009, 203 (04) :685-691

[5]

Beck AT, 1979, Cognitive Therapy of Depression

[6] Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression [J].

Bhagwagar, Z ;

Cowen, PJ ;

Goodwin, GM ;

Harmer, CJ .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (01) :166-168

[7] Depressed patients' perceptions of facial emotions in depressed and remitted states are associated with relapse - A longitudinal study [J].

Bouhuys, AL ;

Geerts, E ;

Gordijn, MCM .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1999, 187 (10) :595-602

[8] A single dose of citalopram increases fear recognition in healthy subjects [J].

Browning, M. ;

Reid, C. ;

Cowen, P. J. ;

Goodwin, G. M. ;

Harmer, C. J. .

JOURNAL OF PSYCHOPHARMACOLOGY, 2007, 21 (07) :684-690

[9] Lateral Prefrontal Cortex Mediates the Cognitive Modification of Attentional Bias [J].

Browning, Michael ;

Holmes, Emily A. ;

Murphy, Susannah E. ;

Goodwin, Guy M. ;

Harmer, Catherine J. .

BIOLOGICAL PSYCHIATRY, 2010, 67 (10) :919-925

[10] Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine [J].

Cardoso de Almeida, J. R. ;

Phillips, M. L. ;

Cerqueira, C. T. ;

Zilberman, M. ;

Lobo, D. ;

Henna, E. ;

Tavares, H. ;

Amaro, E. ;

Gorenstein, C. ;

Gentil, V. ;

Busatto, G. F. .

JOURNAL OF PSYCHOPHARMACOLOGY, 2010, 24 (08) :1165-1174

← 1 2 3 4 5 6 7 8 →