Immunomodulatory properties of human placental mesenchymal stem/stromal cells

被引：84

作者：

Abumaree, M. H. ^{[1
,2
]}

Abomaray, F. M. ^{[3
,4
]}

Alshabibi, M. A. ^{[5
]}

AlAskar, A. S. ^{[1
]}

Kalionis, B. ^{[6
]}

机构：

[1] King Abdul Aziz Med City, Stem Cells & Regenerat Med Dept, King Abdullah Int Med Res Ctr, Minstry Natl Guard Hlth Affairs, POB 22490,Mail Code 1515, Riyadh 11426, Saudi Arabia

[2] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City, Minstry Natl Guard Hlth Affairs, Coll Sci & Hlth Profess, POB 3660,Mail Code 3124, Riyadh 11481, Saudi Arabia

[3] Karolinska Inst, Div Obstet & Gynecol, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden

[4] Karolinska Inst, Ctr Hematol & Regenerat Med, S-14186 Stockholm, Sweden

[5] King Abdulaziz City Sci & Technol, Natl Ctr Stem Cell Technol, Life Sci & Environm Res Inst, POB 6086, Riyadh 11442, Saudi Arabia

[6] Univ Melbourne, Dept Obstet & Gynaecol, Royal Womens Hosp, Dept Maternal Fetal Med,Pregnancy Res Ctr, Parkville, Vic 3052, Australia

来源：

PLACENTA | 2017年 / 59卷

关键词：

Placenta; Mesenchymal stem/stromal cells; Immunosuppression APCs; T cells; B cells; NK cells; DECIDUAL STROMAL CELLS; HUMAN BONE-MARROW; SUPPRESS T-LYMPHOCYTE; UMBILICAL-CORD BLOOD; VERSUS-HOST-DISEASE; STEM-CELLS; IMMUNOSUPPRESSIVE PROPERTIES; AMNIOTIC MEMBRANE; IFN-GAMMA; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.1016/j.placenta.2017.04.003

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Mesenchymal stem/stromal cells (MSCs) are isolated from various fetal and adult tissues such as bone marrow, adipose tissue, cord blood and placenta. Placental MSCs (pMSCs), the main focus of this review, are relatively new MSC types that are not as intensively studied compared with bone marrow-derived MSCs (BMMSCs). MSCs modulate the immune functions of important immune cells involved in alloantigen recognition and elimination, including antigen presenting cells (APCs), T cells, B cells and natural killer (NK) cells. Clinical trials, both completed and underway, employ MSCs to treat various human immunological diseases, such as multiple sclerosis (MS) and type 1 diabetes. However, the mechanisms that mediate the immunosuppressive effects of pMSCs are still largely unknown, and the safety of pMSC use in clinical settings needs further confirmation. Here, we review the current knowledge of the immunosuppressive properties of placental MSCs. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：87 / 95

页数：9

共 95 条

[1]

The role of placenta-derived mesenchymal stem cells in healing of induced full-thickness skin wound in a mouse model [J].

Abd-Allah, Somia H. ;

El-Shal, Amal S. ;

Shalaby, Sally M. ;

Abd-Elbary, Eman ;

Mazen, Nehad F. ;

Abdel Kader, Rania R. .

IUBMB LIFE, 2015, 67 (09) :701-709

[2]

Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta [J].

Abomaray, F. M. ;

Al Jumah, M. A. ;

Alsaad, K. O. ;

Jawdat, D. ;

Al Khaldi, A. ;

AlAskar, A. S. ;

Al Harthy, S. ;

Al Subayyil, A. M. ;

Khatlani, T. ;

Alawad, A. O. ;

Alkushi, A. ;

Kalionis, B. ;

Abumaree, M. H. .

STEM CELLS INTERNATIONAL, 2016, 2016

[3]

Human Chorionic Villous Mesenchymal Stem Cells Modify the Functions of Human Dendritic Cells, and Induce an Anti-Inflammatory Phenotype in CD1+Dendritic Cells [J].

Abomaray, F. M. ;

Al Jumah, M. A. ;

Kalionis, B. ;

AlAskar, A. S. ;

Al Harthy, S. ;

Jawdat, D. ;

Al Khaldi, A. ;

Alkushi, A. ;

Knawy, B. A. ;

Abumaree, M. H. .

STEM CELL REVIEWS AND REPORTS, 2015, 11 (03) :423-441

[4]

Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages [J].

Abumaree, M. H. ;

Al Jumah, M. A. ;

Kalionis, B. ;

Jawdat, D. ;

Al Khaldi, A. ;

Abomaray, F. M. ;

Fatani, A. S. ;

Chamley, L. W. ;

Knawy, B. A. .

STEM CELL REVIEWS AND REPORTS, 2013, 9 (05) :620-641

[5]

Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta [J].

Abumaree, M. H. ;

Al Jumah, M. A. ;

Kalionis, B. ;

Jawdat, D. ;

Al Khaldi, A. ;

AlTalabani, A. A. ;

Knawy, B. A. .

STEM CELL REVIEWS AND REPORTS, 2013, 9 (01) :16-31

[6]

Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells From Decidua Parietalis of Human Term Placenta [J].

Abumaree, Mohamed H. ;

Abomaray, F. M. ;

Alshehri, N. A. ;

Almutairi, A. ;

AlAskar, A. S. ;

Kalionis, B. ;

Al Jumah, M. A. .

REPRODUCTIVE SCIENCES, 2016, 23 (09) :1193-1207

[7]

Mesenchymal-Stem-Cell-Induced Immunoregulation Involves FAS-Ligand-/FAS-Mediated T Cell Apoptosis [J].

Akiyama, Kentaro ;

Chen, Chider ;

Wang, DanDan ;

Xu, Xingtian ;

Qu, Cunye ;

Yamaza, Takayoshi ;

Cai, Tao ;

Chen, WanJun ;

Sun, Lingyun ;

Shi, Songtao .

CELL STEM CELL, 2012, 10 (05) :544-555

[8]

Alikarami Fatemeh, 2015, Avicenna Journal of Medical Biotechnology, V7, P90

[9]

Angoulvant D, 2004, BIORHEOLOGY, V41, P469

[10]

Engraftment potential of human amnion and chorion cells derived from term placenta [J].

Bailo, M ;

Soncini, M ;

Vertua, E ;

Signoroni, PB ;

Sanzone, S ;

Lombardi, G ;

Arienti, D ;

Calamani, F ;

Zatti, D ;

Paul, P ;

Albertini, A ;

Zorzi, F ;

Cavagnini, A ;

Candotti, F ;

Wengler, GS ;

Parolini, O .

TRANSPLANTATION, 2004, 78 (10) :1439-1448

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