Significant role of interleukin-8 in pathogenesis of pulmonary disease due to Mycoplasma pneumoniae infection

被引:35
作者
Narita, M
Tanaka, H
Yamada, S
Abe, S
Ariga, T
Sakiyama, Y
机构
[1] Sapporo Tetsudo JR Hosp, Dept Pediat, Chuo Ku, Sapporo, Hokkaido 0600033, Japan
[2] Sapporo Med Univ, Sch Med, Dept Internal Med 3, Chuo Ku, Sapporo, Hokkaido 0608556, Japan
[3] Hlth Sci Univ Hokkaido, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0028072, Japan
[4] Hokkaido Univ, Sch Med, Dept Gene Therapy, Kita Ku, Sapporo, Hokkaido 0608638, Japan
关键词
D O I
10.1128/CDLI.8.5.1028-1030.2001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We found elevated levels of interleukin-8 in pleural fluid samples from patients with pleural effusion and with a sustained fibrotic change of the lung due to Mycoplasma pneumoniae infection. This result suggests a critical role of interleukin-8 in the pathogenesis of a certain type of pulmonary disease caused by M. pneumoniae.
引用
收藏
页码:1028 / 1030
页数:3
相关论文
共 12 条
[1]   Mycoplasma pneumoniae -: Associated bronchiolitis causing severe restrictive lung disease in adults -: Report of three cases and literature review [J].
Chan, ED ;
Kalayanamit, T ;
Lynch, DA ;
Tuder, R ;
Arndt, P ;
Winn, R ;
Schwarz, MI .
CHEST, 1999, 115 (04) :1188-1194
[2]   Bronchiolitis obliterans organizing pneumonia associated with acute Mycoplasma pneumoniae infection [J].
Llibre, JM ;
Urban, A ;
Garcia, E ;
Carrasco, MA ;
Murcia, C .
CLINICAL INFECTIOUS DISEASES, 1997, 25 (06) :1340-1342
[3]   A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [J].
Medzhitov, R ;
PrestonHurlburt, P ;
Janeway, CA .
NATURE, 1997, 388 (6640) :394-397
[4]   Analysis of mycoplasmal pleural effusion by the polymerase chain reaction [J].
Narita, M ;
Matsuzono, Y ;
Itakura, O ;
Yamada, S ;
Togashi, T .
ARCHIVES OF DISEASE IN CHILDHOOD, 1998, 78 (01) :67-69
[5]   Close association between pulmonary disease manifestation in Mycoplasma pneumoniae infection and enhanced local production of interleukin-18 in the lung, independent of gamma interferon [J].
Narita, M ;
Tanaka, H ;
Abe, S ;
Yamada, S ;
Kubota, M ;
Togashi, T .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2000, 7 (06) :909-914
[6]   Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2:: Role of N-terminal hydrophobic portion in its multiple functions [J].
Nishiguchi, M ;
Matsumoto, M ;
Takao, T ;
Hoshino, M ;
Shimonishi, Y ;
Tsuji, S ;
Begum, NA ;
Takeuchi, O ;
Akira, S ;
Toyoshima, K ;
Seya, T .
JOURNAL OF IMMUNOLOGY, 2001, 166 (04) :2610-2616
[7]   Cytokine gene expression in immune mice reinfected with Mycoplasma pneumoniae: The role of T cell subsets in aggravating the inflammatory response [J].
Opitz, O ;
Pietsch, K ;
Ehlers, S ;
Jacobs, E .
IMMUNOBIOLOGY, 1997, 196 (05) :575-587
[8]   Interleukin-18 (IFNγ-inducing factor) induces IL-8 and IL-1β via TNFα production from non-CD14+ human blood mononuclear cells [J].
Puren, AJ ;
Fantuzzi, G ;
Gu, Y ;
Su, MSS ;
Dinarello, CA .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (03) :711-721
[9]   Severe acute lung injury caused by Mycoplasma pneumoniae:: Potential role for steroid pulses in treatment [J].
Radisic, M ;
Torn, A ;
Gutierrez, P ;
Defranchi, HA ;
Pardo, P .
CLINICAL INFECTIOUS DISEASES, 2000, 31 (06) :1507-1511
[10]  
ROLLINS S, 1986, ARCH PATHOL LAB MED, V110, P34