Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis

被引：5

作者：

Goertsches, Robert ^{[1
]}

Baranzini, Sergio E. ^{[2
]}

Morcillo, Carlos

Nos, Carlos ^{[1
,3
]}

Camina, Montse ^{[1
]}

Oksenberg, Jorge R. ^{[2
]}

Montalban, Xavier ^{[1
]}

Comabella, Manuel ^{[1
]}

机构：

[1] Hosp Univ Vall Hebron, Unitat Neuroimmunol Clin, Barcelona 08035, Spain

[2] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94143 USA

[3] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain

来源：

MULTIPLE SCLEROSIS | 2008年 / 14卷 / 03期

关键词：

polymorphism; multiple sclerosis; open reading frame;

D O I：

10.1177/1352458507083780

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A recent association study has provided evidence that chromosome 10q22.1 may contain candidate genes for multiple sclerosis (MS). We analysed two intronic and a non-synonymous single nucleotide polymorphism (SNP) of the C10orf27 gene in 571 patients with MS (relapsing remitting and primary progressive) and healthy controls. Adjusted comparisons revealed significant association with disease susceptibility for one intronic SNP in RRMS individuals and the amino acid modifying SNP for PPMS cases; the latter may also contribute to faster disease progression. Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis.

引用

页码：412 / 414

页数：3

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