Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

被引：872

作者：

Yamanaka, Koji ^{[1
,2
,3
]}

Chun, Seung Joo ^{[1
,2
]}

Boillee, Severine ^{[1
,2
]}

Fujimori-Tonou, Noriko ^{[3
]}

Yamashita, Hirofumi ^{[3
]}

Gutmann, David H. ^{[4
]}

Takahashi, Ryosuke ^{[5
]}

Misawa, Hidemi ^{[6
]}

Cleveland, Don W. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med & Neurosci, La Jolla, CA 92093 USA

[3] RIKEN, Brain Sci Inst, Yamanaka Res Unit, Wako, Saitama 3510198, Japan

[4] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[5] Kyoto Univ, Grad Sch Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan

[6] Kyoritsu Univ Pharm, Dept Pharmacol, Minato Ku, Tokyo 1058512, Japan

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 03期

关键词：

D O I：

10.1038/nn2047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS.

引用

页码：251 / 253

页数：3

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