Dynamic disulfide combinatorial libraries of cages in water

被引：99

作者：

West, KR ^{[1
]}

Bake, KD ^{[1
]}

Otto, S ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol0507524

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dynamic combinatorial libraries (DCLs) containing water-soluble disulfide-linked cages (alongside macrocyclic structures) have been generated and characterized. Unlike most other strategies for generating molecular cages, the structures are held together by covalent bonds, which are formed under thermodynamic control. The diversity of the cages generated opens new possibilities for a generalized combinatorial strategy toward molecular encapsulation.

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页码：2615 / 2618

页数：4

相关论文

共 57 条

[1] Selecting different complexes from a dynamic combinatorial library of coordination compounds [J].

Albrecht, M ;

Janser, I ;

Runsink, J ;

Raabe, G ;

Weis, P ;

Fröhlich, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (48) :6662-6666

[2]

Albrecht M, 1999, CHEM-EUR J, V5, P48, DOI 10.1002/(SICI)1521-3765(19990104)5:1<48::AID-CHEM48>3.3.CO

[3]

2-Z

[4] Hydrogen-bonded encapsulation complexes in protic solvents [J].

Amaya, T ;

Rebek, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (43) :14149-14156

[5] Synthetic carbohydrate dendrimers .1. A convergent synthesis of carbohydrate-containing dendrimers [J].

Ashton, PR ;

Boyd, SE ;

Brown, CL ;

Jayaraman, N ;

Nepogodiev, SA ;

Stoddart, JF .

CHEMISTRY-A EUROPEAN JOURNAL, 1996, 2 (09) :1115-1128

[6] CHIROSPECIFIC SYNTHESIS OF (1S,3R)-1-AMINO-3-(HYDROXYMETHYL)CYCLOPENTANE, PRECURSOR FOR CARBOCYCLIC NUCLEOSIDE SYNTHESIS - DIECKMANN CYCLIZATION WITH AN ALPHA-AMINO-ACID [J].

BERGMEIER, SC ;

COBAS, AA ;

RAPOPORT, H .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (09) :2369-2376

[7] Thiolated chitosans [J].

Bernkop-Schnürch, A ;

Hornof, M ;

Guggi, D .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) :9-17

[8] Preparation and in vitro characterization of poly(acrylic acid)-cysteine microparticles [J].

Bernkop-Schnürch, A ;

Egger, C ;

Imam, ME ;

Krauland, AH .

JOURNAL OF CONTROLLED RELEASE, 2003, 93 (01) :29-38

[9] Thiolated polymers-thiomers:: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates [J].

Bernkop-Schnürch, A ;

Hornof, M ;

Zoidl, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 260 (02) :229-237

[10] Selection and amplification of a catalyst from a dynamic combinatorial library [J].

Brisig, B ;

Sanders, JKM ;

Otto, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (11) :1270-1273

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