Hematopoietic stem cells

被引：53

作者：

Gunsilius, E ^{[1
]}

Gastl, G ^{[1
]}

Petzer, AL ^{[1
]}

机构：

[1] Univ Innsbruck Hosp, Dept Hematol & Oncol, A-6020 Innsbruck, Austria

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2001年 / 55卷 / 04期

关键词：

characterization; expansion; hematopoietic stem cells; transplantation;

D O I：

10.1016/S0753-3322(01)00051-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The adequate production of blood cells is maintained by a set of immature hematopoietic stem cells (HSC) located in the bone marrow after birth. HSC are able to reconstitute the hematopoietic system in disease-related bone marrow failure and bone marrow aplasia. Nowadays, HSC cells can be mobilized from the bone marrow into the peripheral blood using hematopoietic cytokines, allowing a convenient harvest of these cells for clinical transplantation. This review outlines the development of the hematopoietic system in the embryo and in adults and the characterization, enumeration, purification and ex vivo expansion of HSC for clinical use. Future directions include the genetic manipulation of HSC and the identification/expansion of bone marrow-derived stem cells capable of generating non-hematopoietic tissues. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：186 / 194

页数：9

共 43 条

[1] Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells [J].

Abonour, R ;

Williams, DA ;

Einhorn, L ;

Hall, KM ;

Chen, J ;

Coffman, J ;

Traycoff, CM ;

Bank, A ;

Kato, I ;

Ward, M ;

Williams, SD ;

Hromas, R ;

Robertson, MJ ;

Smith, FO ;

Woo, D ;

Mills, B ;

Srour, EF ;

Cornetta, K .

NATURE MEDICINE, 2000, 6 (06) :652-658

[2] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[3] Cell differentiation - Hepatocytes from nonhepatic adult stem cells [J].

Alison, MR ;

Poulsom, R ;

Jeffery, R ;

Dhillon, AP ;

Quaglia, A ;

Jacob, J ;

Novelli, M ;

Prentice, G ;

Williamson, J ;

Wright, NA .

NATURE, 2000, 406 (6793) :257-257

[4]

BERTONCELLO I, 1991, EXP HEMATOL, V19, P174

[5] Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].

Bjornson, CRR ;

Rietze, RL ;

Reynolds, BA ;

Magli, MC ;

Vescovi, AL .

SCIENCE, 1999, 283 (5401) :534-537

[6] From marrow to brain: Expression of neuronal phenotypes in adult mice [J].

Brazelton, TR ;

Rossi, FMV ;

Keshet, GI ;

Blau, HM .

SCIENCE, 2000, 290 (5497) :1775-1779

[7]

BREEMS DA, 1994, LEUKEMIA, V8, P1095

[8] GENE-MARKING TO TRACE ORIGIN OF RELAPSE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION [J].

BRENNER, MK ;

RILL, DR ;

MOEN, RC ;

KRANCE, RA ;

MIRRO, J ;

ANDERSON, WF ;

IHLE, JN .

LANCET, 1993, 341 (8837) :85-86

[9] Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation [J].

Childs, R ;

Chernoff, A ;

Contentin, N ;

Bahceci, E ;

Schrump, D ;

Leitman, S ;

Read, EJ ;

Tisdale, J ;

Dunbar, C ;

Linehan, WM ;

Young, NS ;

Barrett, AJ ;

Clave, E ;

Epperson, D ;

Mayo, V .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (11) :750-758

[10] BONE MARROW TRANSPLANTATION IN ANIMALS EXPOSED TO WHOLE-BODY RADIATION [J].

CONGDON, CC .

JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY, 1957, 50 :103-108

← 1 2 3 4 5 →