Heterozygous toll-like receptor 2 polymorphism does not affect lipoteichoic acid-induced chemokine and inflammatory responses

被引：50

作者：

von Aulock, S

Schröder, NWJ

Traub, S

Gueinzius, K

Lorenz, E

Hartung, T

Schumann, RR

Hermann, C ^{[1
]}

机构：

[1] Univ Konstanz, D-78457 Constance, Germany

[2] Univ Med Ctr Charite, Inst Mircobiol & Hyg, D-10117 Berlin, Germany

[3] Wake Forest Univ Hlth Sci, Dept Med, Sect Mol Med & Infect Dis, Winston Salem, NC 27157 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 03期

关键词：

D O I：

10.1128/IAI.72.3.1828-1831.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.

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页码：1828 / 1831

页数：4

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