Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs

被引：97

作者：

Aboul-Enein, HY ^{[1
]}

Ali, I ^{[1
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Pharmaceut Anal Lab, Biol & Med Res Dept MBC 03, Riyadh 11211, Saudi Arabia

来源：

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 2001年 / 370卷 / 07期

关键词：

D O I：

10.1007/s002160100884

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Resolution of the enantiomers of (+/-)-econazole, (+/-)-miconazole, and (+/-)-sulconazole has been achieved on different normal-phase chiral amylose columns, Chiralpak AD, AS, and AR. The mobile phase used was hexane-2-propanol-diethylamine, 400:99:1 (v/v). The flow rates of the mobile phase used were 0.50 and 1.00 mL min(-1). The alpha values for the resolved enantiomers of econazole, miconazole, and sulconazole on the chiral phases were in the range 1.63 to 1.04; the R-s values varied from 5.68 to 0.32.

引用

页码：951 / 955

页数：5

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