IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases

被引：39

作者：

Du, Li-Xia ^{[1
]}

Wang, Yan-Qing ^{[1
]}

Hua, Guo-Qiang ^{[2
]}

Mi, Wen-Li ^{[1
]}

机构：

[1] Fudan Univ, Dept Integrat Med & Neurobiol, Acad Integrat Med,State Key Lab Med Neurobiol, Sch Basic Med Sci,Inst Brain Sci Brain Sci,Collab, Shanghai 200032, Peoples R China

[2] Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China

来源：

NEUROSCIENCE | 2018年 / 369卷

基金：

上海市自然科学基金;

关键词：

interleukin-33; ST2; central nervous system diseases; signaling; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ALTERNATIVELY ACTIVATED MACROPHAGES; RECEPTOR ACCESSORY PROTEIN; SYNCYTIAL VIRUS-INFECTION; ISCHEMIC BRAIN-INJURY; INNATE LYMPHOID-CELLS; INTERLEUKIN; 33; ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS;

D O I：

10.1016/j.neuroscience.2017.11.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Interleukin (IL)-33 is a member of the interleukin-1 cytokine family that is produced by many different types of tissues including the central nervous system (CNS). IL-33 mediates its effects via its heterodimeric receptor complex, comprised of ST2 and the IL-1 receptor accessory protein (IL-1RAcp). As a pleiotropic nuclear cytokine, IL-33 is a crucial factor in the development of cardiovascular diseases, allergic diseases, infectious diseases, and autoimmune diseases. Recently, accumulated evidence shows that the IL-33/ST2 axis plays a crucial and diverse role in the pathogenesis of CNS diseases, including neurodegenerative diseases, cerebrovascular diseases, infectious diseases, traumatic CNS injury, chronic pain, etc. In this review, we discuss the recent findings in the cellular signaling of IL-33 and advancement of the role of IL-33 in several CNS diseases, as well as its therapeutic potential for the treatment of those diseases. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：222 / 230

页数：9

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