Hypercalcemia due to all trans retinoic acid in the treatment of acute promyelocytic leukemia potentiated by voriconazole

被引：21

作者：

Bennett, MT

Sirrs, S

Yeung, JK

Smith, CA

机构：

[1] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[2] Univ British Columbia, Div Endocrinol, Vancouver, BC, Canada

[3] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada

[4] Univ British Columbia, Div Hematol, Vancouver, BC, Canada

来源：

LEUKEMIA & LYMPHOMA | 2005年 / 46卷 / 12期

关键词：

hypercalcemia; ATRA; all-trans-retinoic acid; APL; acute promyelocytic leukemia; voriconazole;

D O I：

10.1080/10428190500235298

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All-trans-retinoic acid ( ATRA) is a new and effective treatment of acute promyelocytic leukemia. It has many side-effects, including the retinoic acid syndrome and Sweet's syndrome. There have been only nine cases of hypercalcemia associated with ATRA described in the literature. We discuss a case of hypercalcemia, which we believe was due to inhibition of cytochrome P450 function by voriconizole when used concomitantly with ATRA.

引用

页码：1829 / 1831

页数：3

共 19 条

[1] HYPERCALCEMIA DUE TO ALL-TRANS RETINOIC ACID [J].