Phytochemical and biological studies of Costa Rican Asteraceae part VI -: Studies of ent-kaurane diterpenes from Oyedaea verbesinoides for their inhibitory activity on vascular smooth muscle contraction

被引：20

作者：

Müller, S

Tirapelli, CR

de Oliveira, AM

Murillo, R

Castro, V

Merfort, I

机构：

[1] Univ Freiburg, Inst Pharmaceut Biol, D-79104 Freiburg, Germany

[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049 Ribeirao Preto, SP, Brazil

[3] Univ Sao Paulo, Fac Pharmaceut Sci, Pharmacol Lab, BR-14049 Ribeirao Preto, SP, Brazil

[4] Univ Costa Rica, Escuela Quim, San Jose, Costa Rica

[5] Univ Costa Rica, CIPRONA, San Jose, Costa Rica

来源：

PHYTOCHEMISTRY | 2003年 / 63卷 / 04期

关键词：

Oyedaea verbesinoides; ent-kauranes; smooth muscle; rat aorta;

D O I：

10.1016/S0031-9422(03)00073-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

From the aerial parts of Oyedaea verbesinoides nine ent-kauranes and a sesquiterpene were isolated. ent-9alpha-Hydroxy-kaur-16-en-19-oic acid, ent-15beta-tigloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent-15beta-angeloyloxy-9alpha-hydroxy-kaur-16-en-19-oic acid, ent16alpha-hydroxykaurane and 1alpha-angeloyloxy-carotol are new for the genus or the species and ent-15beta-angeloyloxy-7alpha,9alpha-dihydroxykaur-16-en-19-oic acid is reported for the first time. Structure elucidation was based on one and two dimensional NMR as well as Est and CI-MS analysis. Some diterpenes were proven to exhibit inhibitory effects on smooth muscle contraction on rat aorta. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：391 / 396

页数：6

共 22 条

[1]

SESQUITERPENE LACTONES FROM VIGUIERA-HYPARGYREA [J].