The Molecule Role Ontology: an ontology for annotation of signal transduction pathway molecules in the scientific literature

被引：12

作者：

Yamamoto, S

Asanuma, T

Takagi, T

Fukuda, KI

机构：

[1] Natl Inst Adv Ind Sci & Technol, Computat Biol Res Ctr, Koutou Ku, Tokyo 1350064, Japan

[2] Japan Sci & Technol Agcy, Inst Bioinformat Res & Dev, Tokyo, Japan

[3] Univ Tokyo, Grad Sch Frontier Sci, Chiba, Japan

来源：

COMPARATIVE AND FUNCTIONAL GENOMICS | 2004年 / 5卷 / 6-7期

关键词：

ontology; signal transduction; text mining; scientific literature; pathway database; annotation; manual curation; molecule name; protein name dictionary;

D O I：

10.1002/cfg.432

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In general, it is not easy to specify a single sequence identity for each molecule name that appears in a pathway in the scientific literature. A molecule name may stand for concepts of various granularities, from concrete objects such as H-Ras and ERK1 to abstract concepts or categories such as Ras and MAPK. Typically, the relations among molecule names derive a hierarchical structure; without a proper way to handle this knowledge, it becomes ever more difficult to develop a reliable pathway database. This paper describes an ontology that is designed to annotate molecules in the scientific literature on signal transduction pathways. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：528 / 536

页数：9

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