Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential Sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF)

被引：37

作者：

Suzuki, N ^{[1
]}

Yasaki, S ^{[1
]}

Yasuhara, A ^{[1
]}

Sakamoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 10期

关键词：

indole; sequential cyclization; palladium-catalyzed reaction; 2-ethynylaniline; tetrabutylammnonium fluoride; terminal alkyne;

D O I：

10.1248/cpb.51.1170

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.

引用

页码：1170 / 1173

页数：4

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