Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

被引：402

作者：

Spanswick, D ^{[1
]}

Smith, MA ^{[1
]}

Mirshamsi, S ^{[1
]}

Routh, VH ^{[1
]}

Ashford, MLJ ^{[1
]}

机构：

[1] Univ Aberdeen, Aberdeen Ctr Energy Regulat & Obes, Inst Med Sci, Dept Biomed Sci, Aberdeen AB25 2ZD, Scotland

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/77660

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：757 / 758

页数：2

共 15 条

[1] Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats [J].

Anai, M ;

Funaki, M ;

Ogihara, T ;

Terasaki, J ;

Inukai, K ;

Katagiri, H ;

Fukushima, Y ;

Yazaki, Y ;

Kikuchi, M ;

Oka, Y ;

Asano, T .

DIABETES, 1998, 47 (01) :13-23

[2] GLUCOSE-INDUCED EXCITATION OF HYPOTHALAMIC NEURONS IS MEDIATED BY ATP-SENSITIVE K+ CHANNELS [J].

ASHFORD, MLJ ;

BODEN, PR ;

TREHERNE, JM .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 415 (04) :479-483

[3] TOLBUTAMIDE EXCITES RAT GLUCORECEPTIVE VENTROMEDIAL HYPOTHALAMIC NEURONS BY INDIRECT INHIBITION OF ATP-K+ CHANNELS [J].

ASHFORD, MLJ ;

BODEN, PR ;

TREHERNE, JM .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 101 (03) :531-540

[4] Altered cell surface expression and signaling of leptin receptors containing the fatty mutation [J].

Crouse, JA ;

Elliott, GE ;

Burgess, TL ;

Chiu, L ;

Bennett, L ;

Moore, J ;

Nicolson, M ;

Pacifici, RE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) :18365-18373

[5] Functional properties of leptin receptor isoforms containing the Gln→Pro extracellular domain mutation of the fatty rat [J].

da Silva, BA ;

Bjorbæk, C ;

Uotani, S ;

Flier, JS .

ENDOCRINOLOGY, 1998, 139 (09) :3681-3690

[6] Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line [J].

Harvey, J ;

McKay, NG ;

Walker, KS ;

Van der Kaay, J ;

Downes, CP ;

Ashford, MLJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) :4660-4669

[7] INTRAVENTRICULAR INSULIN REDUCES FOOD-INTAKE AND BODY-WEIGHT OF LEAN BUT NOT OBESE ZUCKER RATS [J].

IKEDA, H ;

WEST, DB ;

PUSTEK, JJ ;

FIGLEWICZ, DP ;

GREENWOOD, MRC ;

PORTE, D ;

WOODS, SC .

APPETITE, 1986, 7 (04) :381-386

[8] Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats [J].

Jiang, ZY ;

Lin, YW ;

Clemont, A ;

Feener, EP ;

Hein, KD ;

Igarashi, M ;

Yamauchi, T ;

White, MF ;

King, GL .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (04) :447-457

[9] Leptin receptor missense mutation in the fatty Zucker rat [J].

Phillips, MS ;

Liu, QY ;

Hammond, HA ;

Dugan, V ;

Hey, PJ ;

Caskey, CT ;

Hess, JF .

NATURE GENETICS, 1996, 13 (01) :18-19

[10] INSULIN IN THE BRAIN - A HORMONAL REGULATOR OF ENERGY-BALANCE [J].

SCHWARTZ, MW ;

FIGLEWICZ, DP ;

BASKIN, DG ;

WOODS, SC ;

PORTE, D .

ENDOCRINE REVIEWS, 1992, 13 (03) :387-414

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