Probing neural circuitry and function with electrical microstimulation

被引:43
作者
Clark, Kelsey L. [1 ]
Armstrong, Katherine M. [1 ]
Moore, Tirin [1 ,2 ]
机构
[1] Stanford Univ, Dept Neurobiol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA
关键词
electrical stimulation; monkey; behaviour; FRONTAL EYE-FIELD; SUPERIOR COLLICULUS; MOTOR CORTEX; CORTICAL MICROSTIMULATION; RHESUS-MONKEY; INFEROTEMPORAL CORTEX; BEHAVIORAL DETECTION; DISCRIMINATION TASK; INTRAPARIETAL AREA; SPATIAL ATTENTION;
D O I
10.1098/rspb.2010.2211
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
Since the discovery of the nervous system's electrical excitability more than 200 years ago, neuroscientists have used electrical stimulation to manipulate brain activity in order to study its function. Microstimulation has been a valuable technique for probing neural circuitry and identifying networks of neurons that underlie perception, movement and cognition. In this review, we focus on the use of stimulation in behaving primates, an experimental system that permits causal inferences to be made about the effect of stimulation-induced activity on the resulting behaviour or neural signals elsewhere in the brain.
引用
收藏
页码:1121 / 1130
页数:10
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