Preparation of polyion complex micelles from poly(ethylene glycol)-block-polyions

被引：32

作者：

Bayo-Puxan, Nuria ^{[1
]}

Dufresne, Marie-Helene ^{[1
]}

Felber, Arnaud E. ^{[1
]}

Castagner, Bastien ^{[1
]}

Leroux, Jean-Christophe ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF CONTROLLED RELEASE | 2011年 / 156卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Polymeric micelle; Polyion complex micelle (PICM); Nucleic acid; Atom transfer radical polymerization (ATRP); Polycation; Polyanion; BLOCK-COPOLYMER MICELLES; WATER-SOLUBLE DRUGS; POLYMERIC MICELLES; SUPRAMOLECULAR ASSEMBLIES; RADICAL POLYMERIZATION; CONTRAST AGENTS; LIPID-BILAYERS; DELIVERY; NANOCARRIERS; OLIGONUCLEOTIDE;

D O I：

10.1016/j.jconrel.2011.07.027

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Polyion complex micelles (PICMs) arise from the spontaneous self-assembly of ionic polymers of opposite charges to form a condensate that is dispersed in aqueous media by a hydrophilic segment, usually poly (ethylene glycol) (PEG), present on at least one of the two ionic polymers. PICMs are used for many applications, especially drug delivery. This protocol paper describes the preparation by atom transfer radical polymerization (ATRP) of diblock copolymers of PEG bearing either positive or negative charges, both of which have been shown to form PICMs. Furthermore, methods of preparation and characterization of PICMs loaded with nucleic acid drugs are presented. (C) 2011 Elsevier B. V. All rights reserved.

引用

页码：118 / 127

页数：10

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