Synthesis of (-)-amphidinolide K fragment C9-C22

被引：50

作者：

Andreou, T ^{[1
]}

Costa, AM ^{[1
]}

Esteban, L ^{[1
]}

Gonzàlez, L ^{[1
]}

Mas, G ^{[1
]}

Vilarrasa, J ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Catalonia, Spain

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 19期

关键词：

D O I：

10.1021/ol051200o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The key fragment (2a or 2b) in a total synthesis of the cytotoxic macrolide (-)-amphidinolide K (1) has been achieved from synthons U-CA (3) and C15-C22 (4), which have both been prepared from glutamic acid in good overall yields.

引用

页码：4083 / 4086

页数：4

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