Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion

被引:40
作者
Bauwens, D
Hantson, P
Laterre, PF
Michaux, L
Latinne, D
De Tourtchaninoff, M
Cosnard, G
Hernalsteen, D
机构
[1] Univ Catholique Louvain, Clin Univ St Luc, Dept Intens Care, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain, Clin Univ St Luc, Dept Hematol, B-1200 Brussels, Belgium
[3] Univ Catholique Louvain, Clin Univ St Luc, Dept Neuroradiol, B-1200 Brussels, Belgium
[4] Univ Catholique Louvain, Clin Univ St Luc, Neurophysiol Lab, B-1200 Brussels, Belgium
关键词
dimethylsulfoxide; seizure; encephalopathy; magnetic resonance imaging;
D O I
10.1080/10428190500235611
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report the case of a patient who received two infusions of dimethylsulfoxide ( DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings ( electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities ( magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO.
引用
收藏
页码:1671 / 1674
页数:4
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