Antimicrobial fragments of the pro-region of cathelicidins and other immune peptides

被引：21

作者：

Anderson, Rachel C. ^{[1
]}

Rehders, Maren ^{[1
]}

Yu, Pak-Lam ^{[1
]}

机构：

[1] Massey Univ, Coll Sci, Inst Technol & Engn, Biotechnol Grp, Palmerston North, New Zealand

来源：

BIOTECHNOLOGY LETTERS | 2008年 / 30卷 / 05期

关键词：

antimicrobial peptides; cathelicidins; cathelin domain; platelet factor 4; T-cell surface glycoprotein CD4;

D O I：

10.1007/s10529-007-9628-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In addition to the numerous cathelicidin peptides that are associated with the antimicrobial activity exhibited by a crude extract from ovine blood, a further three peptides with antimicrobial activity have been identified. These were part of the precursor cathelin domain of cathelicidins, a large fragment of platelet factor 4 and a small peptide similar to signal peptide of the T-cell glycoprotein CD4 precursor. Fragments of proteins that are involved in protecting the host from infection may have a secondary purpose as antimicrobial agents once they have carried out their primary purpose and are cleaved the main protein.

引用

页码：813 / 818

页数：6

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