Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers

被引：91

作者：

Baylor, Stephen M. ^{[1
]}

Hollingworth, Stephen ^{[1
]}

机构：

[1] Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF GENERAL PHYSIOLOGY | 2012年 / 139卷 / 04期

基金：

美国国家卫生研究院;

关键词：

EXTENSOR DIGITORUM LONGUS; RETICULUM CA2+ RELEASE; SKELETAL-MUSCLE; SARCOPLASMIC-RETICULUM; CHARGE MOVEMENT; FLUORESCENT INDICATOR; COOPERATIVE BINDING; SWIMBLADDER MUSCLE; METABOLIC-RATE; TIME-COURSE;

D O I：

10.1085/jgp.201210773

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

In skeletal muscle fibers, action potentials elicit contractions by releasing calcium ions (Ca2+) from the sarcoplasmic reticulum. Experiments on individual mouse muscle fibers micro-injected with a rapidly responding fluorescent Ca2+ indicator dye reveal that the amount of Ca2+ released is three-to fourfold larger in fast-twitch fibers than in slow-twitch fibers, and the proportion of the released Ca2+ that binds to troponin to activate contraction is substantially smaller.

引用

页码：261 / 272

页数：12

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