The influence of hydroquinone on tyrosinase kinetics

被引：34

作者：

Stratford, Michael R. L. ^{[2
]}

Ramsden, Christopher A. ^{[1
]}

Riley, Patrick A. ^{[3
]}

机构：

[1] Univ Keele, Sch Phys & Geog Sci, Lennard Jones Labs, Keele ST5 5BG, Staffs, England

[2] Univ Oxford, Dept Oncol, Gray Inst Radiat Oncol & Biol, Oxford OX3 7DQ, England

[3] Totteridge Inst Adv Studies, London N20 8AB, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2012年 / 20卷 / 14期

关键词：

Tyrosinase; Hydroquinone; Quinone; Quintox mechanism; Oximetry; SUICIDE-INACTIVATION; MECHANISM; AUTOACTIVATION;

D O I：

10.1016/j.bmc.2012.05.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In vitro studies, using combined spectrophotometry and oximetry together with hplc/ms examination of the products of tyrosinase action demonstrate that hydroquinone is not a primary substrate for the enzyme but is vicariously oxidised by a redox exchange mechanism in the presence of either catechol, L-3,4-dihydroxyphenylalanine or 4-ethylphenol. Secondary addition products formed in the presence of hydroquinone are shown to stimulate, rather than inhibit, the kinetics of substrate oxidation. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4364 / 4370

页数：7

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