Complete Nucleotide Sequence of Klebsiella pneumoniae Multidrug Resistance Plasmid pKP048, Carrying blaKPC-2, blaDHA-1, qnrB4, and armA

被引：112

作者：

Jiang, Yan ^{[1
]}

Yu, Dongliang ^{[2
,3
]}

Wei, Zeqing ^{[4
]}

Shen, Ping ^{[4
]}

Zhou, Zhihui ^{[1
]}

Yu, Yunsong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Infect Dis, Hangzhou 310016, Zhejiang, Peoples R China

[2] Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310008, Zhejiang, Peoples R China

[3] Hangzhou Normal Univ, Ctr Biomed & Hlth, Hangzhou 310012, Zhejiang, Peoples R China

[4] Zhejiang Univ, Coll Med, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 09期

关键词：

RIBOSOMAL-RNA METHYLASES; BETA-LACTAMASE; ESCHERICHIA-COLI; GENE; ENTEROBACTERIACEAE; EFFLUX;

D O I：

10.1128/AAC.00137-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Klebsiella pneumoniae multidrug resistance plasmid pKP048 was completely sequenced. This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. Analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile element, conjugal transfer, and a restriction-modification system, showing the strong phylogenetic mosaicism and plasticity of the plasmid.

引用

收藏

页码：3967 / 3969

页数：3

相关论文

共 17 条

[1] Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible [J].

Ambrose, KD ;

Nisbet, R ;

Stephens, DS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (10) :4203-4209

[2] Plasmid-Mediated 16S rRNA Methylases among Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae Isolates [J].

Bercot, Beatrice ;

Poirel, Laurent ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (12) :4526-4527

[3] Dynamics of the IncW genetic backbone imply general trends in conjugative plasmid evolution [J].

Fernandez-Lopez, Raul ;

Garcillan-Barcia, M. Pilar ;

Revilla, Carlos ;

Lazaro, Miguel ;

Vielva, Luis ;

de la Cruz, Fernando .

FEMS MICROBIOLOGY REVIEWS, 2006, 30 (06) :942-966

[4] Novel transferable beta-lactam resistance with cephalosporinase characteristics in Salmonella enteritidis [J].

Gaillot, O ;

Clement, C ;

Simonet, M ;

Philippon, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 39 (01) :85-87

[5] Colistin susceptibility testing by Etest and disk diffusion methods [J].

Galani, Irene ;

Kontopidou, Flora ;

Souli, Maria ;

Rekatsina, Panagiota-Danai ;

Koratzanis, Evangelos ;

Deliolanis, John ;

Giamarellou, Helen .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2008, 31 (05) :434-439

[6] Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum β-lactamase gene blaCTX-M-3 [J].

Golebiewski, M. ;

Kern-Zdanowicz, I. ;

Zienkiewicz, M. ;

Adamczyk, M. ;

Zylinska, J. ;

Baraniak, A. ;

Gniadkowski, M. ;

Bardowski, J. ;

Ceglowski, P. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (11) :3789-3795

[7] Genetic Organization of Transposase Regions Surrounding blaKPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital [J].

Gootz, Thomas D. ;

Lescoe, Mary Kay ;

Dib-Hajj, Fadia ;

Dougherty, Brian A. ;

He, Wen ;

Della-Latta, Phyllis ;

Huard, Richard C. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (05) :1998-2004

[8] qnrB, another plasmid-mediated gene for quinolone resistance [J].

Jacoby, GA ;

Walsh, KE ;

Mills, DM ;

Walker, VJ ;

Oh, H ;

Robicsek, A ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1178-1182

[9] Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies [J].

Kelesidis, Theodoros ;

Karageorgopoulos, Drosos E. ;

Kelesidis, Iosif ;

Falagas, Matthew E. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) :895-904

[10] A first global analysis of plasmid encoded proteins in the ACLAME database [J].

Leplae, Raphael ;

Lima-Mendez, Gipsi ;

Toussaint, Ariane .

FEMS MICROBIOLOGY REVIEWS, 2006, 30 (06) :980-994