4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D-3 receptor partial agonists

被引：16

作者：

Glase, SA ^{[1
]}

Akunne, HC ^{[1
]}

Heffner, TG ^{[1
]}

Johnson, SJ ^{[1
]}

Kesten, SR ^{[1
]}

MacKenzie, RG ^{[1
]}

Manley, PJ ^{[1
]}

Pugsley, TA ^{[1
]}

Wright, JL ^{[1
]}

Wise, LD ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS PHARMACEUT RES,DEPT THERAPEUT,ANN ARBOR,MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00231-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamide dopamine (DA) D-3 receptor agonists has been identified. These compounds were found to be selective for DA D-3 over D-2 receptors and were shown to be partial to full agonists as measured by stimulation of mitogenesis in D-3-transfected CHO p-5 cells. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1361 / 1366

页数：6

共 9 条

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