ABT-773: a new ketolide antibiotic

被引：23

作者：

Dougherty, TJ ^{[1
]}

Barrett, JF ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Microbiol, Wallingford, CT 06492 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2001年 / 10卷 / 02期

关键词：

ABT-773; antibacterial; ermB; ketolide; resistance;

D O I：

10.1517/13543784.10.2.343

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ABT-773 is a new semisynthetic derivative of erythromycin A, the ketolide class of broad spectrum antibacterial agents, in Phase II development by Abbott. With good broad spectrum activity against Gram-positive, some Gram-negative organisms and intracellular bacteria, ABT-773 is being developed as a respiratory agent. Structural changes in the ketolide class agents such as ABT-773 provides expanded activity in vitro against macrolide-resistant strains of Streptococcus pneumoniae and improved activity against MLSB (macrolide-lincosamide-streptogramin) constitutive expressing streptococci.

引用

页码：343 / 351

页数：9

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