Nanomedicine-Nanoscale Drugs and Delivery Systems

被引:147
作者
Singh, Surya [1 ]
机构
[1] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA
关键词
Nanomedicine; Drug-Delivery Systems; Blood-Brain Barrier; Diagnosis; Treatment; Nanoparticles; Quantum Dots; Dendrimers; Nanofibers; Nanotubes; Human Exposure; Safety and Toxicity; SUPERPARAMAGNETIC IRON-OXIDE; SOLID LIPID NANOPARTICLES; WALLED CARBON NANOTUBES; IN-VITRO; QUANTUM DOTS; POLYMERIC NANOPARTICLES; PROSTATE-CANCER; PHOSPHATE NANOPARTICLES; MAGNETIC NANOPARTICLES; BIOLOGICAL-ACTIVITIES;
D O I
10.1166/jnn.2010.3617
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and release from the human body. The biocompatible nanomaterials have been used in biological markers, contrast agents for biological imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. Nanomedicines offer delivery of potential drugs to human organs which were previously beyond reach of microscale drugs due to specific biological barriers. The nanoscale systems work as nanocarriers for the delivery of drugs. The nanocarriers are made of biocompatible and biodegradable materials such as synthetic proteins, peptides, lipids, polysaccharides, biodegradable polymers and fibers. This review article reports the recent developments in the field of nanomedicine covering biodegradable polymers, nanoparticles, cyclodextrin, dendrimeres, liposomes and lipid-based nanocarriers, nanofibers, nanowires and carbon nanotubes and their chemical functionalization for distribution to different organs, their solubility, surface, chemical and biological properties, stability and release systems. The toxicity and safety of nanomaterials on human health is also briefly discussed.
引用
收藏
页码:7906 / 7918
页数:13
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