Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment

被引：151

作者：

Kalluri, HSG ^{[1
]}

Mehta, AK ^{[1
]}

Ticku, MK ^{[1
]}

机构：

[1] Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78284 USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 58卷 / 1-2期

关键词：

chronic ethanol treatment; NMDA receptor subunit; up-regulation;

D O I：

10.1016/S0169-328X(98)00112-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effect of chronic ethanol administration and its withdrawal on the polypeptide levels of NMDA receptor subunits such as NR1, NR2A, and NR2B in the rat cerebral cortex and hippocampus using Western blot analysis technique. Our results indicate that chronic ethanol treatment upregulates NMDA receptor subunits NR1, NR2A, and NR2B (similar to 35%). At 48 h of last dose of ethanol administration, the protein content returned to almost control level, thereby demonstrating the reversibility of the changes. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：221 / 224

页数：4

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